Sedating over the counter
People use nonprescription, or over-the-counter (OTC), drugs to treat less serious conditions that are either transient (will pass relatively quickly), such as the common cold, or chronic (lasting for a long time or recurring frequently), such as allergies. The Food and Drug Administration (FDA) classifies these drugs in over eighty categories such as allergy and cough/cold medications, pain relievers, aids for digestive problems, stimulants, sleep aids, and antibacterial drugs.There are also herbal remedies, which are not regulated by the FDA and which may or may not be effective at treating ailments.Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.Desloratadine inhibited histamine release from human mast cells in vitro." April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.
"We're not saying that there's not a difference," says lead researcher Bruce G.
Bender, Ph D, of National Jewish Medical and Research Center in Denver.
"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.